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 Formulary Chapter 11: Eye - Full Chapter
11.01  Administration of drugs to the eye
11.02  Control of microbial contamination
11.03  Anti-infective eye preparations
11.03.01  Antibacterials
Chloramphenicol
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Formulary Eye drops 0.5%
Eye ointment 1% 
   
Chloramphenicol single use (Minims ® Chloramphenicol )
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Formulary Eye drops 0.5% 
   
Ciprofloxacin (Ciloxan®)
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Formulary

Eye drops 0.3% (contains preservative) 5ml


(Eye ointment discontinued April 2017)

 
   
Fusidic Acid (Fucithalmic®)
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Formulary Eye drops 1% M/R 
   
Gentamicin
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Formulary Eye drops 0.3% (10ml) 
   
levofloxacin (Oftaquix®)
(Preservative Free)
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Restricted Drug Restricted
Amber 2

Available for:

  1. Secondary care – Perioperative Antimicrobial prophylaxis in ophthalmic surgery – formulary status - RED
  2. Penetrating Eye injuries – formulary status: Amber 2- initial prescription to be prescribed by Hospital Dr then subsequent continuation treatment to be prescribed on FP10 and to obtain from GP
 
   
Levofloxacin eye drops 5mg/ml
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Restricted Drug Restricted
Amber 2

Available for:

  1. Secondary care – Perioperative Antimicrobial prophylaxis in ophthalmic surgery – formulary status - RED
  2. Penetrating Eye injuries – formulary status: Amber 2- initial prescription to be prescribed by Hospital Dr then subsequent continuation treatment to be prescribed on FP10 and to obtain from GP
 
   
11.03.02  Antifungals to top
11.03.03  Antivirals
Ganciclovir 0.15% eye gel (Virgan®)
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Formulary  
   
11.03.04  Antiamoebics
11.04  Corticosteroids and other anti-inflammatory preparations
11.04.01  Corticosteroids
Betamethasone (Betnesol)
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Formulary Eye drops 0.1%
Eye ointment 0.1% 
   
Betamethasone 0.1% with Neomycin 0.5%
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Formulary Eye drops (10ml) 
   
Dexamethasone (Maxidex®)
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Formulary Eye drops 0.1% + hypromellose 0.5% 
   
Dexamethasone (Minims® Dexamethasone)
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Formulary Eye drops 0.1% 
   
Dexamethasone 0.1% with Neomycin 0.35% and Polymyxin B sulphate (Maxitrol®)
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Formulary Eye drops (5ml)
Eye ointment (3.5g) 
   
Dexamethasone 700 microgram intravitreal implant (Ozurdex®)
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Restricted Drug Restricted  
Link  NICE TA229: Macular oedema (retinal vein occlusion) - dexamethasone
Link  NICE TA349: Dexamethasone intravitreal implant for treating diabetic macular oedema
   
Fluocinolone intravitreal implant (Iluvien ®)
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Restricted Drug Restricted  
Link  NICE TA301: Diabetic macular oedema - fluocinolone acetonide intravitreal implant (rapid review of TA271)
Link  NICE TA590: Fluocinolone acetonide intravitreal implant for treating recurrent non-infectious uveitis
   
Fluorometholone (FML®)
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Formulary Ophthalmic suspension 0.1% 
   
Prednisolone (Minims® Prednisolone Sodium Phosphate)
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Formulary Eye drops 0.5% 
   
Prednisolone (Pred Forte®)
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Formulary Eye drops 1% 
   
Prednisolone (Predsol®)
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Formulary Eye drops 0.5% 
   
Tobramycin 0.3% with dexamethasone 0.1% eye drops (Tobradex®)
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Formulary  
   
11.04.01  Intravitreal corticosteroids to top
11.04.02  Other anti-inflammatory preparations
Antazoline Sulphate 0.5% with Xylometazoline HCl 0.05% (Otrivine-Antistin®)
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Formulary Otrivine-Antistin eye drops are on the PCT's formulary.
Eye drops (10ml) 
   
Azelastine Hydrochloride (Optilast®)
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Formulary Azelastine eye drops are on the PCT's formulary.
Eye drops 0.05% 
   
Sodium Cromoglicate
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Formulary Eye drops 2% 
   
11.05  Mydriatics and cycloplegics
Ophthalmic Insert: Phenylephrine hydrochloride 5.4mg and Tropicamide 280mcg (Mydriasert®)
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Formulary  
   
Tropicamide with phenylephrine and lidocaine injection (Mydrane®)
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Restricted Drug Restricted 1 ml of solution for injection contains 0.2 mg of tropicamide, 3.1 mg of phenylephrine hydrochloride and 10 mg of lidocaine hydrochloride.

For use by ophthalmology only 
   
11.05  Antimuscarinics
Atropine Sulphate
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Formulary Eye drops 1%
 
   
Atropine Sulphate single use (Minims® Atropine Sulphate)
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Formulary Eye drops 1% 
   
Cyclopentolate Hydrochloride
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Formulary Eye drops 0.5% and 1% 
   
Cyclopentolate Hydrochloride single use (Minims® Cyclopentolate Hydrochloride)
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Formulary Eye drops 0.5% and 1% 
   
Homatropine Hydrobromide
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Formulary Eye drops 1% and 2% 
   
Tropicamide (Mydriacyl®)
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Formulary Eye drops 1% 
   
Tropicamide single use (Minims® Tropicamide)
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Formulary Eye drops 0.5% and 1% 
   
11.05  Sympathomimetics
Phenylephrine Hydrochloride
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Formulary Eye drops 2.5% 
   
Phenylephrine Hydrochloride (Minims® Phenylephrine Hydrochloride )
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Formulary Eye drops 2.5% and 10% 
   
11.06  Treatment of glaucoma to top
11.06  Beta-blockers
Timolol Maleate drops
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First Choice Eye drops 0.25% and 0.5% 
Levobunolol Hydrochloride
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Second Choice Eye drops 0.5% 
   
Timolol 0.1% UDV eye gel (Tiopex®)
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Formulary First line preservative free beta blocker 
   
Levobunolol Hydrochloride 0.5% unit dose vials
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Formulary Preservative free 
   
11.06  Prostaglandin analogues
Latanoprost 0.005% eye drops
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First Choice First line prostaglandin analogue 
Bimatoprost (Lumigan®)
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Second Choice Eye drops 100micrograms/ml

(NOTE 300microgram/ml drops discontinued June 2015)

 
   
Travoprost (Travatan®)
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Third Choice Eye drops 40micrograms/ml 
   
Bimatoprost with Timolol (Ganfort®)
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Formulary Bimatoprost 300micrograms/ml & timolol 5mg/ml drops 
   
Latanoprost 0.005% single use eye drops (Monoprost ®)
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Formulary First line preservative free prostaglandin analogue 
   
Bimatoprost single use eye drops 0.03% (Lumigan)
(®)
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Formulary 2nd line preservative free prostaglandin analogue 
   
Latanoprost 0.005% with Timolol 0.5% eye drops
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Formulary  
   
Travoprost with Timolol (DuoTrav®)
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Formulary Eye drops travoprost 40micrograms/ml & timolol 5mg/ml 
   
11.06  Sympathomimetics
Brimonidine Tartrate (Alphagan®)
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First Choice Eye drops 0.2% 
Brimonidine Tartrate 0.2% with Timolol 0.5% (Combigan®)
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Formulary  
   
11.06  Carbonic anhydrase inhibitors and systemic drugs
Brinzolamide (Azopt®)
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First Choice Eye drops 10mg/ml 
Brinzolamide 1% with Timolol 0.5% (Azarga®)
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Formulary  
   
Brinzolomide 1% with brimonidine 0.2% eye drops (Simbrinza®)
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Restricted Drug Restricted Initiation by ophthalmologists only in patients resistant to standard tratments 
   
Dorzolomide (Trusopt®)
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Restricted Drug Restricted For continuation only
Eye drops 2% 
   
Dorzolomide 2% with Timolol 0.5% (Cosopt®)
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Formulary Eye drops (5ml) 
   
Dorzolomide 2% with Timolol 0.5% unit dose eye drops (Cosopt®)
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Formulary 1st line preservative free carbonic anhydrase inhibitor 
   
Acetazolamide (Diamox®)
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Formulary Tablets 250mg
Injection 500mg 
   
Acetazolamide (Diamox® SR)
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Formulary Capsules 250mg M/R 
   
11.06  Miotics to top
Pilocarpine
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Formulary Eye drops 1%, 2%, and 4%
Eye drops MINIMS 2% (20 x 0.5ml) 
   
11.07  Local anaesthetics
Lidocaine hydrochloride 4% and fluorescein sodium 0.25% drops (Minims® Lidocaine and Fluorescein)
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Formulary  
   
Oxybuprocaine Hydrochloride (Minims® )
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Formulary Eye drops 0.4% 
   
Proxymetacaine Hydrochloride (Minims®)
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Formulary Eye drops 0.5% 
   
Tetracaine Hydrochloride (Minims® Amethocaine Hydrochloride)
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Formulary Eye drops 0.5% and 1% 
   
11.08  Miscellaneous ophthalmic preparations
11.08.01  Tear deficiency, ocular lubricants, and astringents
Hypromellose eye drops 0.3%
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First Choice Hypromellose is on the CCG's formulary as one of the first line ocular lubricants.  
Carbomer 980 0.2% eye gel  (Viscotears®)
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First Choice

CURRENTLY UNAVAILABLE DUE TO MANUFACTURING PROBLEM - for alternative see Clinitas Gel


Liquid gel 0.2%

Viscotears is on the CCG's formulary as one of the first line ocular lubricants.

 
Hypromellose 1% (Isopto Alkaline®)
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First Choice Eye drops 1% (10ml)
Hypromellose is on the CCG's formulary as one of the first line ocular lubricants.  
Polyvinyl alcohol 1.4%, povidone 0.6% Single Dose Units (Liquifilm Tears®)
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First Choice PRESERVATIVE FREE 
Hypromellose 0.3% (Lumecare® Preservative Free Tear Drops )
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First Choice PRESERVATIVE FREE

Not routinely stocked in pharmacy but will be ordered on demand for patients in whom the standard first-line preservative free preparation is not suitable. 
Liquid Paraffin (Lacri-Lube®)
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Second Choice CURRENTLY UNAVAILABLE DUE TO MANUFACTURING PROBLEM - for alternative see Xailin Night

Eye ointment (3.5g)
Lacri-lube is on the CCG's formulary as one of the second line ocular lubricants.  
   
Carmellose Sodium (Celluvisc®)
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Second Choice PRESERVATIVE FREE

Single use: 0.5% and 1% drops 
   
Sodium hyaluronidate 0.1% eye drops (Hylo-Tear®)
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Third Choice PRESERVATIVE FREE
Not routinely stocked in pharmacy. Ordered on demand when requested by Ophthalmology. 
   
Sodium hyaluronidate 0.15% eye drops (Artelac Rebalance®)
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Third Choice Not routinely stocked in pharmacy. Ordered on demand when requested by Ophthalmology. 
   
Sodium hyaluronidate 0.2% eye drops (Hylo-Forte®)
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Third Choice PRESERVATIVE FREE
Not routinely stocked in pharmacy. Ordered on demand when requested by Ophthalmology. 
   
Carbomer 980 0.2% eye gel  (Clinitas gel®)
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Formulary

Temporary replacement for Viscotears due to manufacturing problems.

 
   
Liquid Paraffin (Xailin Night Eye Ointment (5g)®)
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Formulary

Temporary replacement for Lacri-Lube due to manufacturing problems.
Eye ointment, white soft paraffin 57.3%, liquid paraffin 42.5%, wool alcohols 0.2%

 
   
Sodium Chloride (Balanced Salt Solution)
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Formulary Solution (36 x 15ml) 
   
Sodium Chloride (Minims® Saline)
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Formulary Eye drops 0.9% (20 x 0.5ml) 
   
Ciclosporin 0.1% eye drops (Ikervis®)
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Restricted Drug Restricted
Amber 2
For initiation by ophthalmologists only 
Link  NICE TA369: Ciclosporin for treating dry eye disease that has not improved despite treatment with artificial tears
   
11.08.02  Ocular diagnostic and peri-operative preparations and photodynamic treatment
Aflibercept (Eylea®)
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Restricted Drug Restricted
Red
 
Link  NICE TA294: Macular degeneration (wet age-related) - aflibercept (1st line)
Link  NICE TA305: Macular oedema (central retinal vein occlusion) - aflibercept solution for injection
Link  NICE TA307: Colorectal cancer (metastatic) - aflibercept
Link  NICE TA346: Aflibercept for treating diabetic macular oedema
Link  NICE TA409: Aflibercept for treating visual impairment caused by macular oedema after branch retinal vein occlusion
Link  NICE TA486: Aflibercept for treating choroidal neovascularisation
   
Ocriplasmin intravitreal injection (Jetrea®)
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Restricted Drug Restricted  
Link  NICE TA297: Vitreomacular traction - ocriplasmin
   
11.08.02  Ocular diagnostic preparations to top
Fluorescein injection 10% (Anatera(r))
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Formulary  
   
Fluorescein Sodium (Minims®)
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Formulary Eye drops 1% and 2% 
   
11.08.02  Ocular peri-operative drugs
Acetylcholine Chloride (Miochol-E®)
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Formulary Intra-ocular irrigation 10mg/ml 
   
Apraclonidine 0.5% eye drops (Iopidine®)
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Formulary 5ml bottle

For short-term adjunctive treatment of chronic glaucoma in patients not adequately controlled by another drug 
   
Apraclonidine 1% unit dose eye drops (Iopidine®)
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Formulary Ophthalmic solution 1%

For control or prevention of postoperative elevation of intra-ocular pressure after anterior segment laser surgery 
   
Diclofenac Sodium (Voltarol® Ophtha)
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Formulary Eye drops 0.1% 
   
Ketorolac Trometamol (Acular®)
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Formulary Eye drops 0.5% 
   
11.08.02  Subfoveal choroidal neovascularisation
Brolucizumab (Boevu®)
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Restricted Drug Restricted
Red

Intravitreal 19.8 mg brolucizumab in 0.165 ml solution

 

 
Link  Brolucizumab for treating wet age-related macular degeneration
Link  
   
Ranibizumab (Lucentis®)
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Restricted Drug Restricted
High Cost Medicine
CCG
BlueTeq

Intravitreal injection 2.3mg/0.23ml (10mg/ml)

 
Link  NICE TA274: Macular oedema (diabetic)
Link  NICE TA283: Macular oedema (retinal vein occlusion)
Link  NICE TA298: Choroidal neovascularisation (pathological myopia)
   
11.08.02  Vitreomacular traction
11.08.03  Reduction of elevated intra-ocular pressure
11.09  Contact lenses to top
11.99.99.99  Miscellaneous
11.99.99.99  Antifungals
11.99.99.99  Cytotoxics / wound healing modulators
11.99.99.99  Fibrinolytic drugs
11.99.99.99  Glues - ocular to top
11.99.99.99  Immunosuppressants
11.99.99.99  Treatment of burns
11.99.99.99  Visco-elastics
11.99.99.99  Other
 ....
 Non Formulary Items
Acetylcysteine

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Non Formulary
 
Acetylcysteine 5% with Hypromellose 0.35%  (Ilube®)

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Non Formulary Eye drops (10ml)
 
Aciclovir eye ointment 3%  (Zovirax®)

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Non Formulary
Link  Dec 18 - Aciclovir eye ointment discontinuation
 
Alteplase

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Non Formulary
 
Amikacin

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Non Formulary
 
Amo Complete

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Non Formulary
 
Amphotericin

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Non Formulary
 
Azithromycin Dihydrate 1.5% Single Use Eye Drops  (Azyter®)

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Non Formulary
 
Betaxolol Hydrochloride  (Betoptic®)

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Non Formulary Removed Dec 15

Ophthalmic solution 0.5%
Ophthalmic suspension 0.25%
 
Bethamethasone  (Vista-Methasone®)

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Non Formulary
 
Bethamethasone with Neomycin  (Vista-Methasone-N®)

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Non Formulary
 
Bevacizumab  (Avastin®)

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Non Formulary
 
Boston Advance Cleaner

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Non Formulary
 
Boston Advance Conditioning Solution

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Non Formulary
 
Bromofenac 0.09% eye drops  (Yellox ®)

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Non Formulary
 
Carbomers  (GelTears®)

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Non Formulary
 
Carbomers  (Liposic®)

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Non Formulary
 
Carbomers  (liquivisc®)

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Non Formulary
 
Carmellose Sodium 0.5% Single Use Eye Drops  (Carmize® )

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Non Formulary
RedRed
 
Carteolol Hydrochloride  (Teoptic®)

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Non Formulary Removed Dec 15
Eye drops 1% and 2%
 
Ceftazidime

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Non Formulary
 
Cefuroxime

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Non Formulary
 
Chloramphenicol  (Chloromycetin®)

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Non Formulary
 
Controlled Drug  Cocaine

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Non Formulary
 
Dexamethasone with Antibacterials  (Sofradex®)

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Non Formulary
 
Diclofenac Sodium  (Voltarol® Ophtha multidose)

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Non Formulary
 
Dipivefrine Hydrochloride  (Propine®)

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Non Formulary
 
Disodium Edetate 0.37%

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Non Formulary
 
Econazole

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Non Formulary
 
Emedastine  (Emadine®)

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Non Formulary
 
Epinastine Hydrochloride  (Relestat®)

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Non Formulary
 
Erythromycin

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Non Formulary
 
Fluorouracil

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Non Formulary
 
Flurbiprofen Sodium  (Ocufen®)

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Non Formulary
 
Foscarnet

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Non Formulary
 
Ganciclovir

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Non Formulary
 
Gentamicin  (Genticin®)

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Non Formulary
 
Gentamicin single use  (Minims® Gentamicin Sulphate)

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Non Formulary
 
Glycerin

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Non Formulary
 
Hydrocortisone Acetate

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Non Formulary
 
Hydrocortisone Acetate with Neomycin  (Neo-Cortef®)

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Non Formulary
 
Hydroxyethylcellulose  (Minims® Artificial Tears)

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Non Formulary
 
Hydroxypropyl Guar  (Systane®)

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Non Formulary
 
Hydroxypropyl Guar and Sorbitol Eye Drops  (Systane® Ultra )

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Non Formulary
 
Hylauronidase  (Hyalase®)

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Non Formulary
 
Hypromellose  (Isopto Plain®)

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Non Formulary
 
Hypromellose 0.3% with Dextran 70 0.1%  (Tears naturale®)

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Non Formulary
 
Hypromellose single use  (Artelac® SDU)

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Non Formulary
RedRed
 
Indocyanine green

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Non Formulary
 
Ketotifen  (Zaditen®)

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Non Formulary
 
Latanoprost  (Xalatan®)

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Non Formulary See generic product
 
Latanoprost 0.005% with Timolol 0.5%  (Xalacom®)

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Non Formulary See generic equivalent
 
Levobunolol Hydrochloride  (Betagan®)

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Non Formulary
 
Liquid Paraffin  (Lubi-Tears®)

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Non Formulary
 
Liquid Paraffin Eye Ointment  (VitA-POS®)

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Non Formulary
 
Lodoxamide  (Alomide®)

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Non Formulary
 
Loteprednol  (Lotemax®)

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Non Formulary
 
Mitomycin C

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Non Formulary
 
Neodocromil Sodium  (Rapitil®)

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Non Formulary Eye drops 2%
 
Neomycin Sulphate

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Non Formulary
 
Nepafenac  (Nevanac®)

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Non Formulary
 
Ofloxacin  (Exocin®)

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Non Formulary

Ophthalmic solution 0.3% (5ml)

 
Olopatadine  (Opatanol®)

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Non Formulary
 
Oxysept 1 Step

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Non Formulary
 
Paraffin Yellow Soft  (Simple Eye Ointment)

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Non Formulary
RedRed
Ointment (4g)
 
Pegaptanib Sodium  (Macugen®)

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Non Formulary
 
Pilocaprine long acting  (Pilogel®)

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Non Formulary
 
Pilocarpine

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Non Formulary
 
Polyhexanide

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Non Formulary
 
Polymyxin B Sulphate  (Polyfax®)

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Non Formulary

Eye ointment discontinued

 
Polyvinyl Alchohol  (SnoTears®)

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Non Formulary
 
Polyvinyl Alcohol  (Liquifilm Tears®)

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Non Formulary
 
Potassium Ascorbate

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Non Formulary
 
Propamidine Isetionate  (Brolene®)

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Non Formulary
 
Providone  (Oculotect®)

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Non Formulary
 
Proxymetacaine Hydrochloride 0.5% with Fluorescein Sodium 0.25%  (Minims®)
(PRODUCT DISCONTINUED)

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Non Formulary No longer available - replaced with lidocaine/fluorescein drops
 
Rimexolone  (Vexol®)

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Non Formulary
 
Rose Bengal  (Minims® Rose Bengal)

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Non Formulary
 
Saline Solution

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Non Formulary
 
Sodium Chloride

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Non Formulary
 
Sodium Chloride 0.9% Solutions

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Non Formulary
 
Sodium Citrate

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Non Formulary
 
Sodium Cromoglicate  (Catacrom®)

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Non Formulary
 
Sodium Hyaluronate

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Non Formulary
 
Sodium Hyaluronate  (Hylo-Forte®)

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Non Formulary
 
Sodium Hyaluronate  (Hylo-Tear®)

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Non Formulary
 
Sodium Hyaluronate 0.15% Eye Drops  (Lubristil®)

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Non Formulary
 
Sodium Hyaluronate 0.3% Single Use Eye Drops  (Vismed® Gel )

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Non Formulary
 
Sodium Hyaluronate with Lidocaine

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Non Formulary
 
Tafluprost (Preservative Free) 15micrograms/ml  (Saflutan®)

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Non Formulary
 
Tear flow test strips  (Sno Strips)

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Non Formulary
 
Timolol 0.1% Single Use LA Eye Drops  (Tiopex®)

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Non Formulary
 
Timolol Maleate  (timoptol®)

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Non Formulary
 
Timolol Maleate Once-daily  (Timoptol®-LA)

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Non Formulary
 
Tissue Adhesive  (Histacryl®)

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Non Formulary
 
Total Care Daily Cleaner

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Non Formulary
 
Total Care Disinfecting and Wetting Solution

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Non Formulary
 
Trifluorothymidine

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Non Formulary
 
Vancomycin

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Non Formulary
 
Verteporfin  (Visudyne®)

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Non Formulary
 
Zinc Sulphate

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Non Formulary
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Amber 1

"Amber 1" - These are medicines that require significant monitoring and the decision to treat with an AMBER medicine should be made by specialists only  

Amber 2

"Amber 2" - These are medicines that require little or no monitoring by the GP, but should only be prescribed in general practice after they have been recommended following specialist referral.  

Red

"Red" - Secondary care only  

RedRed

"Double Red" - NOT recommended for prescribing in either primary or secondary care  

Grey

Traffic light status to be confirmed  

Green

May be prescribed in primary and secondary care  

netFormulary