Formulary Chapter 11: Eye - Full Chapter
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11.01 |
Administration of drugs to the eye |
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11.02 |
Control of microbial contamination |
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11.03 |
Anti-infective eye preparations |
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11.03.01 |
Antibacterials |
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Chloramphenicol
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Formulary
|
Eye drops 0.5%
Eye ointment 1%
|
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Chloramphenicol single use (Minims ® Chloramphenicol )
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Formulary
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Eye drops 0.5%
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Ciprofloxacin (Ciloxan®)
|
Formulary
|
Eye drops 0.3% (contains preservative) 5ml
(Eye ointment discontinued April 2017)
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Fusidic Acid (Fucithalmic®)
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Formulary
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Eye drops 1% M/R
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Gentamicin
|
Formulary
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Eye drops 0.3% (10ml)
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Levofloxacin eye drops 5mg/ml
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Restricted
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Available for:
- Secondary care – Perioperative Antimicrobial prophylaxis in ophthalmic surgery – formulary status - RED
- Penetrating Eye injuries – formulary status: Amber 2- initial prescription to be prescribed by Hospital Dr then subsequent continuation treatment to be prescribed on FP10 and to obtain from GP
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Ofloxacin (Exocin®)
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Formulary
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Ophthalmic solution 0.3% (5ml)
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11.03.02 |
Antifungals |
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11.03.03 |
Antivirals |
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Ganciclovir 0.15% eye gel (Virgan®)
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Formulary
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11.03.04 |
Antiamoebics |
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11.04 |
Corticosteroids and other anti-inflammatory preparations |
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11.04.01 |
Corticosteroids |
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Betamethasone (Betnesol)
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Formulary
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Eye drops 0.1%
Eye ointment 0.1%
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Betamethasone 0.1% with Neomycin 0.5%
|
Formulary
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Eye drops (10ml)
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Dexamethasone (Maxidex®)
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Formulary
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Eye drops 0.1% + hypromellose 0.5%
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Dexamethasone (Minims® Dexamethasone)
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Formulary
|
Eye drops 0.1%
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Dexamethasone 0.1% with Neomycin 0.35% and Polymyxin B sulphate (Maxitrol®)
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Formulary
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Eye drops (5ml)
Eye ointment (3.5g)
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Dexamethasone 700 microgram intravitreal implant (Ozurdex®)
|
Restricted
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NICE TA229: Macular oedema (retinal vein occlusion) - dexamethasone
NICE TA349: Dexamethasone intravitreal implant for treating diabetic macular oedema
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Fluocinolone intravitreal implant (Iluvien ®)
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Restricted
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NICE TA301: Diabetic macular oedema - fluocinolone acetonide intravitreal implant (rapid review of TA271)
NICE TA590: Fluocinolone acetonide intravitreal implant for treating recurrent non-infectious uveitis
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Fluorometholone (FML®)
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Formulary
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Ophthalmic suspension 0.1%
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Prednisolone (Minims® Prednisolone Sodium Phosphate)
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Formulary
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Eye drops 0.5%
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Prednisolone (Pred Forte®)
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Formulary
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Eye drops 1%
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Prednisolone (Predsol®)
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Formulary
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Eye drops 0.5%
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Tobramycin 0.3% with dexamethasone 0.1% eye drops (Tobradex®)
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Formulary
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11.04.01 |
Intravitreal corticosteroids |
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11.04.02 |
Other anti-inflammatory preparations |
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Antazoline Sulphate 0.5% with Xylometazoline HCl 0.05% (Otrivine-Antistin®)
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Formulary
|
Otrivine-Antistin eye drops are on the PCT's formulary.
Eye drops (10ml)
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Azelastine Hydrochloride (Optilast®)
|
Formulary
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Azelastine eye drops are on the PCT's formulary.
Eye drops 0.05%
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Sodium Cromoglicate
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Formulary
|
Eye drops 2%
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11.05 |
Mydriatics and cycloplegics |
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Ophthalmic Insert: Phenylephrine hydrochloride 5.4mg and Tropicamide 280mcg (Mydriasert®)
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Formulary
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Tropicamide with phenylephrine and lidocaine injection (Mydrane®)
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Restricted
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1 ml of solution for injection contains 0.2 mg of tropicamide, 3.1 mg of phenylephrine hydrochloride and 10 mg of lidocaine hydrochloride.
For use by ophthalmology only
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11.05 |
Antimuscarinics |
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Atropine Sulphate
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Formulary
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Eye drops 1%
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Atropine Sulphate single use (Minims® Atropine Sulphate)
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Formulary
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Eye drops 1%
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Cyclopentolate Hydrochloride
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Formulary
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Eye drops 0.5% and 1%
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Cyclopentolate Hydrochloride single use (Minims® Cyclopentolate Hydrochloride)
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Formulary
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Eye drops 0.5% and 1%
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Homatropine Hydrobromide
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Formulary
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Eye drops 1% and 2%
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Tropicamide (Mydriacyl®)
|
Formulary
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Eye drops 1%
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Tropicamide single use (Minims® Tropicamide)
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Formulary
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Eye drops 0.5% and 1%
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11.05 |
Sympathomimetics |
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Phenylephrine Hydrochloride
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Formulary
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Eye drops 2.5%
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Phenylephrine Hydrochloride (Minims® Phenylephrine Hydrochloride )
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Formulary
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Eye drops 2.5% and 10%
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11.06 |
Treatment of glaucoma |
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11.06 |
Beta-blockers |
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Timolol Maleate drops
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First Choice
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Eye drops 0.25% and 0.5%
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Levobunolol Hydrochloride
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Second Choice
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Eye drops 0.5%
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Timolol 0.1% UDV eye gel (Tiopex®)
|
Formulary
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First line preservative free beta blocker
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Levobunolol Hydrochloride 0.5% unit dose vials
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Formulary
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Preservative free
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11.06 |
Prostaglandin analogues |
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Latanoprost 0.005% eye drops
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First Choice
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First line prostaglandin analogue
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Bimatoprost (Lumigan®)
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Second Choice
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Eye drops 100micrograms/ml
(NOTE 300microgram/ml drops discontinued June 2015)
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Travoprost (Travatan®)
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Third Choice
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Eye drops 40micrograms/ml
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Bimatoprost with Timolol (Ganfort®)
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Formulary
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Bimatoprost 300micrograms/ml & timolol 5mg/ml drops
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Latanoprost 0.005% single use eye drops (Monoprost ®)
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Formulary
|
First line preservative free prostaglandin analogue
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Bimatoprost single use eye drops 0.03% (Lumigan) (®)
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Formulary
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2nd line preservative free prostaglandin analogue
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Latanoprost 0.005% with Timolol 0.5% eye drops
|
Formulary
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Travoprost with Timolol (DuoTrav®)
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Formulary
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Eye drops travoprost 40micrograms/ml & timolol 5mg/ml
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11.06 |
Sympathomimetics |
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Brimonidine Tartrate (Alphagan®)
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First Choice
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Eye drops 0.2%
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Brimonidine Tartrate 0.2% with Timolol 0.5% (Combigan®)
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Formulary
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11.06 |
Carbonic anhydrase inhibitors and systemic drugs |
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Brinzolamide (Azopt®)
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First Choice
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Eye drops 10mg/ml
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Brinzolamide 1% with Timolol 0.5% (Azarga®)
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Formulary
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Brinzolomide 1% with brimonidine 0.2% eye drops (Simbrinza®)
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Restricted
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Initiation by ophthalmologists only in patients resistant to standard tratments
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Dorzolomide (Trusopt®)
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Restricted
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For continuation only
Eye drops 2%
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Dorzolomide 2% with Timolol 0.5% (Cosopt®)
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Formulary
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Eye drops (5ml)
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Dorzolomide 2% with Timolol 0.5% unit dose eye drops (Cosopt®)
|
Formulary
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1st line preservative free carbonic anhydrase inhibitor
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Acetazolamide (Diamox®)
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Formulary
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Tablets 250mg
Injection 500mg
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Acetazolamide (Diamox® SR)
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Formulary
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Capsules 250mg M/R
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11.06 |
Miotics |
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Pilocarpine
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Formulary
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Eye drops 1%, 2%, and 4%
Eye drops MINIMS 2% (20 x 0.5ml)
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11.07 |
Local anaesthetics |
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Lidocaine hydrochloride 4% and fluorescein sodium 0.25% drops (Minims® Lidocaine and Fluorescein)
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Formulary
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Oxybuprocaine Hydrochloride (Minims® )
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Formulary
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Eye drops 0.4%
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Proxymetacaine Hydrochloride (Minims®)
|
Formulary
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Eye drops 0.5%
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Tetracaine Hydrochloride (Minims® Amethocaine Hydrochloride)
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Formulary
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Eye drops 0.5% and 1%
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11.08 |
Miscellaneous ophthalmic preparations |
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11.08.01 |
Tear deficiency, ocular lubricants, and astringents |
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Hypromellose eye drops 0.3%
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First Choice
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Hypromellose is on the CCG's formulary as one of the first line ocular lubricants.
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Carbomer 980 0.2% eye gel (Viscotears®)
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First Choice
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CURRENTLY UNAVAILABLE DUE TO MANUFACTURING PROBLEM - for alternative see Clinitas Gel
Liquid gel 0.2% Viscotears is on the CCG's formulary as one of the first line ocular lubricants.
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Hypromellose 1% (Isopto Alkaline®)
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First Choice
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Eye drops 1% (10ml)
Hypromellose is on the CCG's formulary as one of the first line ocular lubricants.
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Polyvinyl alcohol 1.4%, povidone 0.6% Single Dose Units (Liquifilm Tears®)
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First Choice
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PRESERVATIVE FREE
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Hypromellose 0.3% (Lumecare® Preservative Free Tear Drops )
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First Choice
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PRESERVATIVE FREE
Not routinely stocked in pharmacy but will be ordered on demand for patients in whom the standard first-line preservative free preparation is not suitable.
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Liquid Paraffin (Lacri-Lube®)
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Second Choice
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CURRENTLY UNAVAILABLE DUE TO MANUFACTURING PROBLEM - for alternative see Xailin Night
Eye ointment (3.5g)
Lacri-lube is on the CCG's formulary as one of the second line ocular lubricants.
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Carmellose Sodium (Celluvisc®)
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Second Choice
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PRESERVATIVE FREE
Single use: 0.5% and 1% drops
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Sodium hyaluronidate 0.1% eye drops (Hylo-Tear®)
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Third Choice
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PRESERVATIVE FREE Not routinely stocked in pharmacy. Ordered on demand when requested by Ophthalmology.
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Sodium hyaluronidate 0.15% eye drops (Artelac Rebalance®)
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Third Choice
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Not routinely stocked in pharmacy. Ordered on demand when requested by Ophthalmology.
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Sodium hyaluronidate 0.2% eye drops (Hylo-Forte®)
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Third Choice
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PRESERVATIVE FREE Not routinely stocked in pharmacy. Ordered on demand when requested by Ophthalmology.
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Carbomer 980 0.2% eye gel (Clinitas gel®)
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Formulary
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Temporary replacement for Viscotears due to manufacturing problems.
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Liquid Paraffin (Xailin Night Eye Ointment (5g)®)
|
Formulary
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Temporary replacement for Lacri-Lube due to manufacturing problems. Eye ointment, white soft paraffin 57.3%, liquid paraffin 42.5%, wool alcohols 0.2%
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Sodium Chloride (Balanced Salt Solution)
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Formulary
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Solution (36 x 15ml)
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Sodium Chloride (Minims® Saline)
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Formulary
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Eye drops 0.9% (20 x 0.5ml)
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Ciclosporin 0.1% eye drops (Ikervis®)
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Restricted
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For initiation by ophthalmologists only
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NICE TA369: Ciclosporin for treating dry eye disease that has not improved despite treatment with artificial tears
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11.08.02 |
Ocular diagnostic and peri-operative preparations and photodynamic treatment |
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Aflibercept (Eylea®)
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Restricted
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NICE TA294: Macular degeneration (wet age-related) - aflibercept (1st line)
NICE TA305: Macular oedema (central retinal vein occlusion) - aflibercept solution for injection
NICE TA307: Colorectal cancer (metastatic) - aflibercept
NICE TA346: Aflibercept for treating diabetic macular oedema
NICE TA409: Aflibercept for treating visual impairment caused by macular oedema after branch retinal vein occlusion
NICE TA486: Aflibercept for treating choroidal neovascularisation
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Ocriplasmin intravitreal injection (Jetrea®)
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Restricted
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NICE TA297: Vitreomacular traction - ocriplasmin
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11.08.02 |
Ocular diagnostic preparations |
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Fluorescein injection 10% (Anatera(r))
|
Formulary
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Fluorescein Sodium (Minims®)
|
Formulary
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Eye drops 1% and 2%
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11.08.02 |
Ocular peri-operative drugs |
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Acetylcholine Chloride (Miochol-E®)
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Formulary
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Intra-ocular irrigation 10mg/ml
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Apraclonidine 0.5% eye drops (Iopidine®)
|
Formulary
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5ml bottle
For short-term adjunctive treatment of chronic glaucoma in patients not adequately controlled by another drug
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Apraclonidine 1% unit dose eye drops (Iopidine®)
|
Formulary
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Ophthalmic solution 1%
For control or prevention of postoperative elevation of intra-ocular pressure after anterior segment laser surgery
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Diclofenac Sodium (Voltarol® Ophtha)
|
Formulary
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Eye drops 0.1%
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Ketorolac Trometamol (Acular®)
|
Formulary
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Eye drops 0.5%
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11.08.02 |
Subfoveal choroidal neovascularisation |
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Ranibizumab (Lucentis®)
|
Restricted


|
Intravitreal injection 2.3mg/0.23ml (10mg/ml)
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NICE TA274: Macular oedema (diabetic)
NICE TA283: Macular oedema (retinal vein occlusion)
NICE TA298: Choroidal neovascularisation (pathological myopia)
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11.08.02 |
Vitreomacular traction |
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11.08.03 |
Reduction of elevated intra-ocular pressure |
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11.09 |
Contact lenses |
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11.99.99.99 |
Miscellaneous |
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11.99.99.99 |
Antifungals |
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11.99.99.99 |
Cytotoxics / wound healing modulators |
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11.99.99.99 |
Fibrinolytic drugs |
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11.99.99.99 |
Glues - ocular |
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11.99.99.99 |
Immunosuppressants |
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11.99.99.99 |
Treatment of burns |
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11.99.99.99 |
Visco-elastics |
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11.99.99.99 |
Other |
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.... |
Non Formulary Items |
Acetylcysteine

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Non Formulary
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Acetylcysteine 5% with Hypromellose 0.35% (Ilube®)

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Non Formulary
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Eye drops (10ml) |
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Aciclovir eye ointment 3% (Zovirax®)

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Non Formulary
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Dec 18 - Aciclovir eye ointment discontinuation
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Alteplase

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Non Formulary
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Amikacin

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Non Formulary
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Amo Complete

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Non Formulary
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Amphotericin

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Non Formulary
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Azithromycin Dihydrate 1.5% Single Use Eye Drops (Azyter®)

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Non Formulary
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Betaxolol Hydrochloride (Betoptic®)

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Non Formulary
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Removed Dec 15
Ophthalmic solution 0.5%
Ophthalmic suspension 0.25% |
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Bethamethasone (Vista-Methasone®)

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Non Formulary
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Bethamethasone with Neomycin (Vista-Methasone-N®)

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Non Formulary
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Bevacizumab (Avastin®)

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Non Formulary
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Boston Advance Cleaner

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Non Formulary
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Boston Advance Conditioning Solution

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Non Formulary
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Bromofenac 0.09% eye drops (Yellox ®)

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Non Formulary
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Carbomers (GelTears®)

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Non Formulary
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Carbomers (Liposic®)

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Non Formulary
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Carbomers (liquivisc®)

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Non Formulary
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Carmellose Sodium 0.5% Single Use Eye Drops (Carmize® )

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Non Formulary
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Carteolol Hydrochloride (Teoptic®)

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Non Formulary
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Removed Dec 15
Eye drops 1% and 2% |
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Ceftazidime

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Non Formulary
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Cefuroxime

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Non Formulary
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Chloramphenicol (Chloromycetin®)

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Non Formulary
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Cocaine

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Non Formulary
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Dexamethasone with Antibacterials (Sofradex®)

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Non Formulary
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Diclofenac Sodium (Voltarol® Ophtha multidose)

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Non Formulary
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Dipivefrine Hydrochloride (Propine®)

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Non Formulary
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Disodium Edetate 0.37%

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Non Formulary
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Econazole

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Non Formulary
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Emedastine (Emadine®)

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Non Formulary
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Epinastine Hydrochloride (Relestat®)

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Non Formulary
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Erythromycin

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Non Formulary
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Fluorouracil

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Non Formulary
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Flurbiprofen Sodium (Ocufen®)

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Non Formulary
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Foscarnet

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Non Formulary
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Ganciclovir

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Non Formulary
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Gentamicin (Genticin®)

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Non Formulary
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Gentamicin single use (Minims® Gentamicin Sulphate)

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Non Formulary
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Glycerin

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Non Formulary
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Hydrocortisone Acetate

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Non Formulary
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Hydrocortisone Acetate with Neomycin (Neo-Cortef®)

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Non Formulary
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Hydroxyethylcellulose (Minims® Artificial Tears)

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Non Formulary
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Hydroxypropyl Guar (Systane®)

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Non Formulary
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Hydroxypropyl Guar and Sorbitol Eye Drops (Systane® Ultra )

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Non Formulary
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Hylauronidase (Hyalase®)

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Non Formulary
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Hypromellose (Isopto Plain®)

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Non Formulary
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Hypromellose 0.3% with Dextran 70 0.1% (Tears naturale®)

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Non Formulary
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Hypromellose single use (Artelac® SDU)

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Non Formulary
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Indocyanine green

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Non Formulary
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Ketotifen (Zaditen®)

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Non Formulary
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Latanoprost (Xalatan®)

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Non Formulary
|
See generic product |
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Latanoprost 0.005% with Timolol 0.5% (Xalacom®)

|
Non Formulary
|
See generic equivalent |
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Levobunolol Hydrochloride (Betagan®)

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Non Formulary
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levofloxacin (Oftaquix®)

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Non Formulary
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Liquid Paraffin (Lubi-Tears®)

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Non Formulary
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Liquid Paraffin Eye Ointment (VitA-POS®)

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Non Formulary
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Lodoxamide (Alomide®)

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Non Formulary
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Loteprednol (Lotemax®)

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Non Formulary
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Mitomycin C

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Non Formulary
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Neodocromil Sodium (Rapitil®)

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Non Formulary
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Eye drops 2%
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Neomycin Sulphate

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Non Formulary
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Nepafenac (Nevanac®)

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Non Formulary
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Olopatadine (Opatanol®)

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Non Formulary
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Oxysept 1 Step

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Non Formulary
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Paraffin Yellow Soft (Simple Eye Ointment)

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Non Formulary
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Ointment (4g) |
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Pegaptanib Sodium (Macugen®)

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Non Formulary
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Pilocaprine long acting (Pilogel®)

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Non Formulary
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Pilocarpine

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Non Formulary
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Polyhexanide

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Non Formulary
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Polymyxin B Sulphate (Polyfax®)

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Non Formulary
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Eye ointment discontinued |
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Polyvinyl Alchohol (SnoTears®)

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Non Formulary
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Polyvinyl Alcohol (Liquifilm Tears®)

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Non Formulary
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Potassium Ascorbate

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Non Formulary
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Propamidine Isetionate (Brolene®)

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Non Formulary
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Providone (Oculotect®)

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Non Formulary
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Proxymetacaine Hydrochloride 0.5% with Fluorescein Sodium 0.25% (Minims®) (PRODUCT DISCONTINUED)

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Non Formulary
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No longer available - replaced with lidocaine/fluorescein drops |
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Rimexolone (Vexol®)

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Non Formulary
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Rose Bengal (Minims® Rose Bengal)

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Non Formulary
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Saline Solution

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Non Formulary
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Sodium Chloride

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Non Formulary
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|
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Sodium Chloride 0.9% Solutions

|
Non Formulary
|
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Sodium Citrate

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Non Formulary
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Sodium Cromoglicate (Catacrom®)

|
Non Formulary
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Sodium Hyaluronate

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Non Formulary
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Sodium Hyaluronate (Hylo-Forte®)

|
Non Formulary
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Sodium Hyaluronate (Hylo-Tear®)

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Non Formulary
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Sodium Hyaluronate 0.15% Eye Drops (Lubristil®)

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Non Formulary
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Sodium Hyaluronate 0.3% Single Use Eye Drops (Vismed® Gel )

|
Non Formulary
|
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Sodium Hyaluronate with Lidocaine

|
Non Formulary
|
|
|
Tafluprost (Preservative Free) 15micrograms/ml (Saflutan®)

|
Non Formulary
|
|
|
Tear flow test strips (Sno Strips)

|
Non Formulary
|
|
|
Timolol 0.1% Single Use LA Eye Drops (Tiopex®)

|
Non Formulary
|
|
|
Timolol Maleate (timoptol®)

|
Non Formulary
|
|
|
Timolol Maleate Once-daily (Timoptol®-LA)

|
Non Formulary
|
|
|
Tissue Adhesive (Histacryl®)

|
Non Formulary
|
|
|
Total Care Daily Cleaner

|
Non Formulary
|
|
|
Total Care Disinfecting and Wetting Solution

|
Non Formulary
|
|
|
Trifluorothymidine

|
Non Formulary
|
|
|
Vancomycin

|
Non Formulary
|
|
|
Verteporfin (Visudyne®)

|
Non Formulary
|
|
|
Zinc Sulphate

|
Non Formulary
|
|
|
|
Key |
|
|
Cytotoxic Drug
|
|
Controlled Drug
|
|
High Cost Medicine
|
|
Cancer Drugs Fund
|
|
NHS England |
|
Homecare |
|
CCG |
|
Traffic Light Status Information
Status |
Description |

|
"Amber 1" - These are medicines that require significant monitoring and the decision to treat with an AMBER medicine should be made by specialists only |

|
"Amber 2" - These are medicines that require little or no monitoring by the GP, but should only be prescribed in general practice after they have been recommended following specialist referral. |

|
"Red" - Secondary care only |

|
"Double Red" - NOT recommended for prescribing in either primary or secondary care |

|
Traffic light status to be confirmed |

|
May be prescribed in primary and secondary care |
|
|
|