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 Formulary Chapter 10: Musculoskeletal and joint diseases - Full Chapter
10.01.03  Expand sub section  Drugs which suppress the rheumatic disease process
Golimumab Injection 50mg (Simponi®)
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Restricted Drug Restricted  
Link  NICE TA220: Psoriatic arthritis - golimumab
Link  NICE TA225: Rheumatoid arthritis (after the failure of previous anti-rheumatic drugs) - golimumab
Link  NICE TA329: Infliximab, adalimumab and golimumab for treating moderately to severely active ulcerative colitis after the failure of conventional therapy (including a review of TA140 and TA262)
Link  NICE TA383: TNF-alpha inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis
Link  NICE TA497: Golimumab for treating non-radiographic axial spondyloarthritis
   
Guselkumab solution for injection 100mg (Tremfya®)
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Formulary
High Cost Medicine
CCG

Pre-filled syringes

 
Link  NICE TA521: Guselkumab for treating moderate to severe plaque psoriasis
   
Tofacitinib tablets 5mg (Xeljanz®)
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Restricted Drug Restricted
Red
High Cost Medicine
 
Link  NICE TA480: Tofacitinib for moderate to severe rheumatoid arthritis
Link  NICE TA543: Tofacitinib for treating active psoriatic arthritis after inadequate response to DMARDs
Link  NICE TA547: Tofacitinib for moderately to severely active ulcerative colitis
   
10.01.03  Expand sub section  Gold
Auranofin (Ridaura®)
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Formulary Tablets 3mg 
   
Sodium Aurothomalate (Myocrisin®)
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Formulary Injection 10mg/0.5ml and 50mg/0.5ml 
   
10.01.03  Expand sub section  Penicillamine
Penicillamine
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Formulary
Amber 1
Tablets 125mg and 250mg 
   
10.01.03  Expand sub section  Antimalarials
Chloroquine Phosphate
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Formulary Tablets 250mg (base 155mg) 
   
Hydroxychloroquine Sulphate (Plaquenil®)
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Formulary
Amber 1
Tablets 200mg 
   
10.01.03  Expand sub section  Drugs affecting the immune response to top
Abatacept (Orencia®)
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Restricted Drug Restricted
Red
 
Link  NICE TA195: Rheumatoid arthritis - drugs for treatment after failure of a TNF inhibitor
Link  NICE TA280: Rheumatoid arthritis - abatacept (2nd line)
   
Adalimumab (Humira®)
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Restricted Drug Restricted
Red
Injection 40mg/0.8ml 
Link  NICE TA130: Rheumatoid arthritis - adalimumab, etanercept and infliximab
Link  NICE TA195: Rheumatoid arthritis - drugs for treatment after failure of a TNF inhibitor
Link  NICE TA383: TNF-alpha inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis
   
Anakinra (Kineret®)
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Restricted Drug Restricted Injection 100mg/0.67ml 
   
Azathioprine
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Formulary
Amber 1
Tablets 25mg and 50mg 
   
Baricitinib tablets (Olumiant®)
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Restricted Drug Restricted
Red
High Cost Medicine
-2mg and 4mg tablets 
Link  NICE TA466: Baricitinib for moderate to severe rheumatoid arthritis
   
Brodalumab 210mg/1.5ml solution for injection pre-filled syringes  (Kyntheum®)
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Formulary
Red
High Cost Medicine
CCG
 
Link  NICE TA511: Brodalumab for treating moderate to severe plaque psoriasis
   
Certolizumab Pegol Injection 200mg (Cimzia®)
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Restricted Drug Restricted
Red
 
Link  NICE TA186: Rheumatoid arthritis - certolizumab pegol
Link  NICE TA574: Certolizumab pegol for treating moderate to severe plaque psoriasis
Link  NICE: TA383 TNF-alpha inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis
Link  NICE TA415:Certolizumab pegol for treating rheumatoid arthritis after inadequate response to a TNF-alpha inhibitor
Link  NICE TA445: Certolizumab pegol and secukinumab for treating active psoriatic arthritis after inadequate response to DMARDs
   
Ciclosporin
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Formulary
Amber 1
Capsules 25mg, 50mg and 100mg
Oral solution 100mg/ml
Concentrate for infusion 50mg/ml 
   
Dupilumab (Dupixent®)
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Formulary  
Link  NICE TA534: Dupilumab for treating moderate to severe atopic dermatitis
   
Etanercept (Enbrel®)
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Formulary
Red
Injection 50mg 
Link  NICE TA130: Rheumatoid arthritis - adalimumab, etanercept and infliximab
Link  NICE TA195: Rheumatoid arthritis - drugs for treatment after failure of a TNF inhibitor
Link  NICE TA383: TNF-alpha inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis
   
Infliximab (Remicade®)
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Formulary
Amber 1
Infusion 100mg 
Link  NICE TA130: Rheumatoid arthritis - adalimumab, etanercept and infliximab
Link  NICE TA134: Psoriasis - infliximab
Link  NICE TA195: Rheumatoid arthritis - drugs for treatment after failure of a TNF inhibitor
Link  NICE TA383: TNF-alpha inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis
   
Leflunomide (Arava®)
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Formulary
Amber 1
Tablets 10mg, 20mg and 100mg 
   
Methotrexate (Metoject®)
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Formulary
Red
Pre-filled pens: 7.5mg, 10mg, 12.5mg, 15mg, 17.5mg, 20mg, 22.5mg and 25mg 
   
Cytotoxic Drug Methotrexate tablets 2.5mg
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Formulary
Amber 1
For rheumatology indications and myasthenia gravis. For other indications, see relevant chapters.
 
   
Risankizumab (Skyrizi®)
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Restricted Drug Restricted  
Link  NICE TA596: Risankizumab for treating moderate to severe plaque psoriasis
   
Rituximab (MabThera®)
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Restricted Drug Restricted
Red
 
Link  NICE TA195: Rheumatoid arthritis - drugs for treatment after failure of a TNF inhibitor
Link  NICE TA308: Vasculitis (anti-neutrophil cytoplasmic antibody-associated) - rituximab (with glucocorticoids)
   
Tocilizumab (RoActemra®)
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Formulary
Red
Infusion 80mg/4ml 
Link  NICE TA238: Arthritis (juvenile idiopathic, systemic) - tocilizumab
Link  NICE TA247: Rheumatoid arthritis - tocilizumab
Link  NICE TA518: Tocilizumab for treating giant cell arteritis
   
10.01.03  Expand sub section  Cytokine modulators
10.01.03  Expand sub section  Sulfasalazine
Sulfasalazine
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Formulary Tablets 500mg 
   
Sulfasalazine (Salazopyrin EN-Tabs®)
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Formulary E/C tablets 500mg 
   
 ....
 Non Formulary Items
Belimumab Infusion  (Benlysta®)

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Non Formulary 120mg and 400mg Vial
Link  NICE TA397: Belimumab for treating active autoantibody-positive systemic lupus erythematosus
 
Methotrexate Pre-Filled Injection  (Ebetrex®)

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Non Formulary
 
Penicillamine  (Distamine®)

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Non Formulary
Amber 1
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
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Link to adult BNF
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Link to children's BNF
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Link to SPCs
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Amber 1

"Amber 1" - These are medicines that require significant monitoring and the decision to treat with an AMBER medicine should be made by specialists only  

Amber 2

"Amber 2" - These are medicines that require little or no monitoring by the GP, but should only be prescribed in general practice after they have been recommended following specialist referral.  

Red

"Red" - Secondary care only  

RedRed

"Double Red" - NOT recommended for prescribing in either primary or secondary care  

Grey

Traffic light status to be confirmed  

Green

May be prescribed in primary and secondary care  

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